Paediatric rheumatology Methotrexate bioavailability after oral and subcutaneous administration in children with juvenile idiopathic arthritis
نویسندگان
چکیده
Objective To compare the bioavailability of oral and subcutaneous methotrexate (MTX) in children with juvenile idiopathic
منابع مشابه
Methotrexate efficacy and tolerability after switching from oral to subcutaneous route of administration in juvenile idiopathic arthritis
OBJECTIVES Methotrexate (MTX) is one of the most frequently used, highly effective disease-modifying drugs in juvenile idiopathic arthritis (JIA) therapy. The drug can be administered orally or subcutaneously, but the efficacy and tolerance of these two routes of administration raise doubts in JIA patients. The aim of the study was to evaluate MTX efficacy and tolerability after switching from ...
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BACKGROUND There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We sought to assess current practice patterns within a large cohort of children with juvenile uveitis. METHODS This is a cross-sectional cohort study of patients with uveitis enrolled in the Childhood Arthritis and Rheumatology Re...
متن کاملMethotrexate efficacy, but not its intolerance, is associated with the dose and route of administration
BACKGROUND There is a lack of published evidence on the importance of methotrexate (MTX) dose and route of administration on both its efficacy and adverse events in children with Juvenile Idiopathic Arthritis (JIA). We aimed to document our clinical practice based on the treat-to-target approach in order to support the concept that better therapeutic effect achieved with an optimal dose of pare...
متن کاملEfficacy of Subcutaneous Methotrexate in JIA Patients Who have Failed to Improve with Oral Methotrexate
Methotrexate is the most commonly used disease modifying anti-rheumatic drug (DMARDs) for rheumatoid arthritis1. However, some patients are intolerant to oral MTX despite folate supplementation and some patients do not respond adequately2. The route of administration of MTX in children with juvenile idiopathic arthritis (JIA) is not standardized and varies according to patient’s and treating ph...
متن کاملThe Efficacy of Subcutaneous Versus Oral Methotrexate in Patients with Juvenile Idiopathic Arthritis
The aim of modern treatment of JIA is rapid induction of disease control to prevent joint damage, to maximize physical function and to achieve a normal lifestyle2. Medications that slow the progression of Rheumatoid arthritis are called disease modifying anti Rheumatic drugs (DMARDs). American College of Rheumatology (ACR) recommends early use of DMARDs, so that they can slow or help inhibition...
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تاریخ انتشار 2006